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Gene Ontology Classifications
bone morphogenetic protein receptor, type 1A

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Bmpr1a. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Babitt JL et al. (2006) Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet, 38:531-9. (PubMed:16604073)
  2. Cho G et al. (2009) SUMO interaction motifs in Sizn1 are required for promyelocytic leukemia protein nuclear body localization and for transcriptional activation. J Biol Chem, 284:19592-600. (PubMed:19416967)
  3. Davis S et al. (2004) BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning. Dev Biol, 270:47-63. (PubMed:15136140)
  4. Davis SW et al. (2007) Noggin regulates Bmp4 activity during pituitary induction. Dev Biol, 305:145-60. (PubMed:17359964)
  5. Degenkolbe E et al. (2013) A GDF5 point mutation strikes twice--causing BDA1 and SYNS2. PLoS Genet, 9:e1003846. (PubMed:24098149)
  6. Di-Gregorio A et al. (2007) BMP signalling inhibits premature neural differentiation in the mouse embryo. Development, 134:3359-69. (PubMed:17699604)
  7. Eblaghie MC et al. (2006) Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells. Dev Biol, 291:67-82. (PubMed:16414041)
  8. Jamin SP et al. (2002) Requirement of Bmpr1a for Mullerian duct regression during male sexual development. Nat Genet, 32:408-10. (PubMed:12368913)
  9. Kua HY et al. (2012) c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression. Nat Cell Biol, 14:727-37. (PubMed:22729085)
  10. Liu W et al. (2005) Distinct functions for Bmp signaling in lip and palate fusion in mice. Development, 132:1453-61. (PubMed:15716346)
  11. Ma L et al. (2005) Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning. Development, 132:5601-11. (PubMed:16314491)
  12. May SR et al. (2004) A Titin mutation defines roles for circulation in endothelial morphogenesis. Dev Biol, 270:31-46. (PubMed:15136139)
  13. Mazerbourg S et al. (2005) Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses. J Biol Chem, 280:32122-32. (PubMed:16049014)
  14. Miura S et al. (2006) BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites. Development, 133:3767-75. (PubMed:16943278)
  15. Morikawa Y et al. (2009) BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways. Development, 136:3575-84. (PubMed:19793887)
  16. Murali D et al. (2005) Distinct developmental programs require different levels of Bmp signaling during mouse retinal development. Development, 132:913-23. (PubMed:15673568)
  17. Namiki M et al. (1997) A kinase domain-truncated type I receptor blocks bone morphogenetic protein-2-induced signal transduction in C2C12 myoblasts. J Biol Chem, 272:22046-52. (PubMed:9268344)
  18. Rountree RB et al. (2004) BMP receptor signaling is required for postnatal maintenance of articular cartilage. PLoS Biol, 2:e355. (PubMed:15492776)
  19. Soshnikova N et al. (2003) Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb. Genes Dev, 17:1963-8. (PubMed:12923052)
  20. Villacorte M et al. (2010) Antagonistic crosstalk of Wnt/beta-catenin/Bmp signaling within the Apical Ectodermal Ridge (AER) regulates interdigit formation. Biochem Biophys Res Commun, 391:1653-7. (PubMed:20043884)
  21. Wine-Lee L et al. (2004) Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord. Development, 131:5393-403. (PubMed:15469980)
  22. Yang L et al. (2006) Isl1Cre reveals a common Bmp pathway in heart and limb development. Development, 133:1575-85. (PubMed:16556916)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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