Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of S100a1. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of S100a1
  • is located in the following cellular components:
    • sarcoplasmic reticulum ^[1]
• The gene product of S100a1 has been shown to bind to the gene products of S100a4. ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of S100a1:
  • participates in the following biological processes:
    • negative regulation of transcription from RNA polymerase II promoter
    • positive regulation of voltage-gated calcium channel activity
  • performs the following molecular functions:
    • ATPase binding
    • calcium ion binding
    • calcium-dependent protein binding
    • identical protein binding
    • protein homodimerization activity
    • S100 protein binding
  • is located in the following cellular components:
    • A band
    • cytoplasm
    • I band
    • M band
    • neuron projection
    • nucleus
    • sarcoplasmic reticulum
    • Z disc

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe S100a1 indicates that it:
  • performs the following molecular functions:
    • metal ion binding

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References

1. Kiewitz R et al. (2003) Ca2+ -dependent interaction of S100A1 with the sarcoplasmic reticulum Ca2+ -ATPase2a and phospholamban in the human heart. Biochem Biophys Res Commun, 306:550-7. (PubMed:12804600)
2. Tarabykina S et al. (2000) Heterocomplex formation between metastasis-related protein S100A4 (Mts1) and S100A1 as revealed by the yeast two-hybrid system. FEBS Lett, 475:187-91. (PubMed:10869553)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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