Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits several functions, including hemi-methylated DNA-binding activity; histone binding activity; and ubiquitin protein ligase activity. Involved in maintenance of DNA methylation; negative regulation of transcription by RNA polymerase II; and protein ubiquitination. Localizes to nuclear heterochromatin; nuclear matrix; and replication fork. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hindlimb phalanx; and sensory organ. Orthologous to human UHRF1 (ubiquitin like with PHD and ring finger domains 1).