Automated description from the Alliance of Genome Resources
Exhibits several functions, including hemi-methylated DNA-binding activity; histone binding activity; and ubiquitin protein ligase activity. Involved in cellular protein modification process; maintenance of DNA methylation; and negative regulation of transcription by RNA polymerase II. Localizes to the nuclear heterochromatin; nuclear matrix; and replication fork. Orthologous to human UHRF1 (ubiquitin like with PHD and ring finger domains 1).