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Gene Ontology Classifications
3-phosphoinositide dependent protein kinase 1

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GO curators for mouse genes have assigned the following annotations to the gene product of Pdpk1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Chaurasia B et al. (2010) Phosphoinositide-dependent kinase 1 provides negative feedback inhibition to Toll-like receptor-mediated NF-kappaB activation in macrophages. Mol Cell Biol, 30:4354-66. (PubMed:20584979)
  2. Dong LQ et al. (1999) Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta. J Biol Chem, 274:8117-22. (PubMed:10075713)
  3. Ito K et al. (2009) PDK1 coordinates survival pathways and beta-adrenergic response in the heart. Proc Natl Acad Sci U S A, 106:8689-94. (PubMed:19429709)
  4. Michel JJ et al. (2005) Spatial restriction of PDK1 activation cascades by anchoring to mAKAPalpha. Mol Cell, 20:661-72. (PubMed:16337591)
  5. Munton RP et al. (2007) Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol Cell Proteomics, 6:283-93. (PubMed:17114649)
  6. Primo L et al. (2007) Essential role of PDK1 in regulating endothelial cell migration. J Cell Biol, 176:1035-47. (PubMed:17371830)
  7. Shumilina E et al. (2010) Phosphoinositide-dependent kinase PDK1 in the regulation of Ca2+ entry into mast cells. Cell Physiol Biochem, 26:699-706. (PubMed:21063107)
  8. Torbett NE et al. (2003) Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1. J Biol Chem, 278:32344-51. (PubMed:12783890)
  9. Westmoreland JJ et al. (2009) Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells. Dev Biol, 334:285-98. (PubMed:19635472)

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Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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