Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Capn7. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Capn7:
  • participates in the following biological processes:
    • self proteolysis
  • performs the following molecular functions:
    • MIT domain binding

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Summary text based on GO annotations supported by structural data

• Capn7 encodes a protein or proteins that contain the following InterPro domains: MIT, Peptidase C2, calpain family, Peptidase C2, calpain, catalytic domain, Peptidase C2, calpain, domain III, Peptidase C2, calpain, large subunit, domain III, indicating that the gene product:
  • participates in the following biological processes:
    • proteolysis
  • performs the following molecular functions:
    • calcium-dependent cysteine-type endopeptidase activity
  • is located in the following cellular components:
    • intracellular

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Capn7 indicates that it:
  • participates in the following biological processes:
    • proteolysis
  • performs the following molecular functions:
    • cysteine-type peptidase activity
    • hydrolase activity
    • peptidase activity
  • is located in the following cellular components:
    • nucleus

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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