Automated description from the Alliance of Genome Resources
Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding activity; and sequence-specific DNA binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of transcription by RNA polymerase II; and positive regulation of DNA damage response, signal transduction by p53 class mediator. Localizes to the chromatin. Used to study Miller-Dieker lissencephaly syndrome. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; immune system; and trophectoderm. Orthologous to human HIC1 (HIC ZBTB transcriptional repressor 1).