Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Trp73. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of July 3, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however, the biological validity and the full-length nature of most variants have not been determined. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Trp73
  • participates in the following biological processes:
    • apoptotic process ^[8]
    • cell cycle arrest ^[8]
    • negative regulation of apoptotic process ^[1]
    • negative regulation of JUN kinase activity ^[3]
    • negative regulation of neuron apoptotic process ^{[6, 7]}
    • positive regulation of transcription, DNA-dependent ^[8]
    • release of cytochrome c from mitochondria ^[3]
  • performs the following molecular functions:
    • DNA binding ^[2]
    • sequence-specific DNA binding transcription factor activity ^[8]
  • is located in the following cellular components:
    • nucleus ^{[3, 4, 5]}
• The gene product of Trp73 has been shown to bind to the gene products of Mapk8. ^[3] Researchers have inferred, based on physical interactions, that the gene product of Trp73
  • performs the following molecular functions:
    • p53 binding ^[6]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Trp73
  • participates in the following biological processes:
    • cerebrospinal fluid secretion ^[9]
    • digestive tract morphogenesis ^[9]
    • forebrain development ^[5]
    • hippocampus development ^[9]
    • inflammatory response ^[9]
    • negative regulation of neuron apoptotic process ^{[3, 6, 7]}
    • neuron development ^[7]
    • positive regulation of cell size ^{[3, 7]}
    • post-embryonic development ^{[3, 9]}
    • response to DNA damage stimulus ^[8]
• Researchers have inferred, based on genetic interactions, that the gene product of Trp73
  • participates in the following biological processes:
    • regulation of neuron apoptotic process based on interactions with Trp53 ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Trp73:
  • participates in the following biological processes:
    • activation of MAPK activity
    • cellular response to UV
    • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
    • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
    • mitotic cell cycle G1/S transition DNA damage checkpoint
    • negative regulation of neuron differentiation
    • negative regulation of transcription from RNA polymerase II promoter
    • positive regulation of apoptotic process
    • positive regulation of oligodendrocyte differentiation
    • positive regulation of transcription from RNA polymerase II promoter
    • positive regulation of transcription, DNA-dependent
    • response to DNA damage stimulus
    • response to gamma radiation
    • response to X-ray
  • performs the following molecular functions:
    • chromatin binding
    • damaged DNA binding
    • double-stranded DNA binding
    • identical protein binding
    • protein kinase binding
    • sequence-specific DNA binding
    • sequence-specific DNA binding transcription factor activity
    • transcription factor binding
    • transcription regulatory region DNA binding
  • is located in the following cellular components:
    • chromatin
    • cytosol
    • nucleus
    • transcription factor complex

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Summary text based on GO annotations supported by structural data

• Trp73 encodes a protein or proteins that contain the following InterPro domains: p53 tumour suppressor family, p53, DNA-binding domain, p53, tetramerisation domain, p53-like transcription factor, DNA-binding, p53/RUNT-type transcription factor, DNA-binding domain, Sterile alpha motif domain, Sterile alpha motif, type 2, Sterile alpha motif/pointed domain, indicating that the gene product:
  • participates in the following biological processes:
    • protein tetramerization
    • regulation of transcription, DNA-dependent

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Trp73 indicates that it:
  • participates in the following biological processes:
    • cell cycle
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • metal ion binding
  • is located in the following cellular components:
    • cytoplasm

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References

1. Ishii H et al. (2005) Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. Proc Natl Acad Sci U S A, 102:9655-60. (PubMed:15983387)
2. Kulesz-Martin M et al. (2005) Melanocyte and keratinocyte carcinogenesis: p53 family protein activities and intersecting mRNA expression profiles. J Investig Dermatol Symp Proc, 10:142-52. (PubMed:16363065)
3. Lee AF et al. (2004) Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms. J Neurosci, 24:9174-84. (PubMed:15483136)
4. Maisse C et al. (2003) p73 and p63 protein stability: the way to regulate function? Biochem Pharmacol, 66:1555-61. (PubMed:14555234)
5. Meyer G et al. (2004) Developmental roles of p73 in Cajal-Retzius cells and cortical patterning. J Neurosci, 24:9878-87. (PubMed:15525772)
6. Pozniak CD et al. (2000) An anti-apoptotic role for the p53 family member, p73, during developmental neuron death [see comments] Science, 289:304-6. (PubMed:10894779)
7. Pozniak CD et al. (2002) p73 is required for survival and maintenance of CNS neurons. J Neurosci, 22:9800-9. (PubMed:12427836)
8. Tomasini R et al. (2005) TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity. Oncogene, 24:8093-104. (PubMed:16044147)
9. Yang A et al. (2000) p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature, 404:99-103. (PubMed:10716451)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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