Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Taf1. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of April 10, 2009. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. This gene is part of a complex transcriptional unit (TAF1/DYT3), wherein some products share exons with TAF1 as well as additional exons downstream.[provided by RefSeq, Aug 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Taf1
  • participates in the following biological processes:
    • histone acetylation ^[1]
  • performs the following molecular functions:
    • DNA binding ^[3]
    • histone acetyltransferase activity ^[1]
  • is located in the following cellular components:
    • nucleus ^[2]
    • pronucleus ^[4]
• The gene product of Taf1 has been shown to bind to the gene products of Taf7. ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Taf1:
  • participates in the following biological processes:
    • G1 phase of mitotic cell cycle
    • histone acetylation
    • peptidyl-serine phosphorylation
    • peptidyl-threonine phosphorylation
    • positive regulation of proteasomal ubiquitin-dependent protein catabolic process
    • positive regulation of transcription from RNA polymerase II promoter
    • protein autophosphorylation
  • performs the following molecular functions:
    • histone acetyl-lysine binding
    • histone acetyltransferase activity
    • p53 binding
    • protein serine/threonine kinase activity
    • TBP-class protein binding
    • transcription coactivator activity
    • transcription factor binding
  • is located in the following cellular components:
    • MLL1 complex
    • nucleus
    • transcription factor TFIID complex

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Summary text based on GO annotations supported by structural data

• Taf1 encodes a protein or proteins that contain the following InterPro domains: Bromodomain, Bromodomain, conserved site, TAFII-230 TBP-binding, Transcription initiation factor TFIID subunit 1, animal, Transcription initiation factor TFIID subunit 1, domain of unknown function, indicating that the gene product:
  • participates in the following biological processes:
    • DNA-dependent transcription, initiation
    • regulation of transcription, DNA-dependent

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Taf1 indicates that it:
  • participates in the following biological processes:
    • cell cycle
    • phosphorylation
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • ATP binding
    • kinase activity
    • nucleotide binding
    • transferase activity

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References

1. Gegonne A et al. (2001) TAFII55 binding to TAFII250 inhibits its acetyltransferase activity. Proc Natl Acad Sci U S A, 98:12432-7. (PubMed:11592977)
2. Kamileri I et al. (2012) Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Proc Natl Acad Sci U S A, 109:2995-3000. (PubMed:22323595)
3. Tatarakis A et al. (2008) Dominant and redundant functions of TFIID involved in the regulation of hepatic genes. Mol Cell, 31:531-43. (PubMed:18722179)
4. Wang K et al. (2006) Regulated expression of TAF1 in 1-cell mouse embryos. Zygote, 14:209-15. (PubMed:16822332)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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