Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Sumo3. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] SUMO proteins, such as SUMO3, and ubiquitin (see MIM 191339) posttranslationally modify numerous cellular proteins and affect their metabolism and function. However, unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (Su and Li, 2002 [PubMed 12383504]).[supplied by OMIM, Mar 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Sumo3
  • participates in the following biological processes:
    • positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process ^[2]
    • protein localization to nucleus ^[2]
    • protein sumoylation ^{[1, 2]}
  • performs the following molecular functions:
    • SUMO ligase activity ^{[1, 2]}
  • is located in the following cellular components:
    • nuclear body ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Sumo3:
  • participates in the following biological processes:
    • protein sumoylation

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Sumo3 indicates that it:
  • is located in the following cellular components:
    • cytoplasm

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References

1. Gomez-del Arco P et al. (2005) Ikaros SUMOylation: switching out of repression. Mol Cell Biol, 25:2688-97. (PubMed:15767674)
2. Lee J et al. (2008) Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex. Mol Cell Biol, 28:6056-65. (PubMed:18644859)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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