Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Fem1b. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Fem1b
  • participates in the following biological processes:
    • protein ubiquitination ^[2]
  • is located in the following cellular components:
    • nucleus ^[1]
• The gene product of Fem1b has been shown to bind to the gene products of Ankrd37, Nkx3-1. ^{[2, 3]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Fem1b
  • participates in the following biological processes:
    • branching involved in prostate gland morphogenesis ^[3]
    • epithelial cell maturation ^[3]
    • epithelial cell maturation involved in prostate gland development ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Fem1b:
  • participates in the following biological processes:
    • regulation of apoptotic process
    • regulation of DNA damage checkpoint
    • regulation of ubiquitin-protein ligase activity
  • performs the following molecular functions:
    • death receptor binding
    • ubiquitin-protein ligase activity
  • is located in the following cellular components:
    • cytoplasm
    • nucleus

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Fem1b indicates that it:
  • participates in the following biological processes:
    • apoptotic process

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References

1. Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell, 5:420-33. (PubMed:19796622)
2. Shi YQ et al. (2011) Mouse Fem1b interacts with and induces ubiquitin-mediated degradation of Ankrd37. Gene, 485:153-9. (PubMed:21723927)
3. Wang X et al. (2008) Mouse Fem1b interacts with the Nkx3.1 homeoprotein and is required for proper male secondary sexual development. Dev Dyn, 237:2963-2972. (PubMed:18816836)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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