Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in several processes, including osteoclast differentiation; phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of mast cell degranulation. Acts upstream of or within cell migration and integrin-mediated signaling pathway. Located in membrane raft. Is expressed in basal forebrain; cerebral cortex; diencephalon; and intestine smooth muscle circular layer. Orthologous to human GAB2 (GRB2 associated binding protein 2).