Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cx3cr1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Cx3cr1
  • participates in the following biological processes:
    • cerebral cortex cell migration ^[1]
    • cytokine-mediated signaling pathway ^[2]
    • macrophage chemotaxis ^[3]
    • microglial cell activation involved in immune response ^[1]
    • negative regulation of angiogenesis ^[3]
    • negative regulation of apoptotic process ^[2]
  • performs the following molecular functions:
    • cytokine receptor activity ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cx3cr1:
  • participates in the following biological processes:
    • chemokine-mediated signaling pathway
    • G-protein coupled receptor signaling pathway
    • negative regulation of cell migration
    • positive regulation of angiogenesis
  • performs the following molecular functions:
    • C-X3-C chemokine receptor activity
  • is located in the following cellular components:
    • neuron projection
    • neuronal cell body membrane
    • perinuclear region of cytoplasm

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Summary text based on GO annotations supported by structural data

• Cx3cr1 encodes a protein or proteins that contain the following InterPro domains: CX3C chemokine fractalkine receptor, GPCR, rhodopsin-like, GPCR, rhodopsin-like, 7TM, indicating that the gene product:
  • participates in the following biological processes:
    • cell adhesion
    • chemokine-mediated signaling pathway
    • chemotaxis
    • elevation of cytosolic calcium ion concentration
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cx3cr1 indicates that it:
  • participates in the following biological processes:
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane
    • plasma membrane

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References

1. Cardona AE et al. (2006) Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci, 9:917-24. (PubMed:16732273)
2. Landsman L et al. (2009) CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival. Blood, 113:963-72. (PubMed:18971423)
3. Lu P et al. (2008) Protective Roles of the Fractalkine/CX3CL1-CX3CR1 Interactions in Alkali-Induced Corneal Neovascularization through Enhanced Antiangiogenic Factor Expression. J Immunol, 180:4283-91. (PubMed:18322241)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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