Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Enam. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of December 14, 2012. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Dental enamel forms the outer cap of teeth and is the hardest substance found in vertebrates. This gene encodes the largest protein in the enamel matrix of developing teeth. The protein is involved in the mineralization and structural organization of enamel. Defects in this gene result in amelogenesis imperfect type 1C.[provided by RefSeq, Oct 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Enam
  • participates in the following biological processes:
    • amelogenesis ^{[1, 2, 3]}
    • odontogenesis of dentin-containing tooth ^[4]

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Enam indicates that it:
  • participates in the following biological processes:
    • biomineral tissue development
  • is located in the following cellular components:
    • extracellular region
    • proteinaceous extracellular matrix
• Annotations directly to molecular function for the gene Enam indicate that MGI curators have found no experimental data [literature] to support further annotation to this category at this time.

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References

1. Hu JC et al. (2008) Enamel defects and ameloblast-specific expression in Enam knock-out/lacz knock-in mice. J Biol Chem, 283:10858-71. (PubMed:18252720)
2. Kang MS et al. (2008) Epstein-Barr virus nuclear antigen 1 does not cause lymphoma in C57BL/6J mice. J Virol, 82:4180-3. (PubMed:18256159)
3. Masuya H et al. (2005) Enamelin (Enam) is essential for amelogenesis: ENU-induced mouse mutants as models for different clinical subtypes of human amelogenesis imperfecta (AI). Hum Mol Genet, 14:575-83. (PubMed:15649948)
4. Seedorf H et al. (2004) Amelogenesis imperfecta in a new animal model--a mutation in chromosome 5 (human 4q21). J Dent Res, 83:608-12. (PubMed:15271968)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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