Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables cytoskeletal protein binding activity; protein lysine deacetylase activity; and ubiquitin binding activity. Involved in several processes, including positive regulation of mitophagy in response to mitochondrial depolarization; positive regulation of peptidyl-serine phosphorylation; and protein destabilization. Acts upstream of or within several processes, including aggresome assembly; erythrocyte enucleation; and neuron projection morphogenesis. Located in several cellular components, including dendrite; microtubule cytoskeleton; and perikaryon. Part of protein-containing complex. Is expressed in several structures, including central nervous system; early embryo; gut gland; lung; and metanephros. Human ortholog(s) of this gene implicated in chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia. Orthologous to human HDAC6 (histone deacetylase 6).