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Gene Ontology Classifications
Symbol
Name
ID
Hdac6
histone deacetylase 6
MGI:1333752

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Hdac6. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. . () , :. (PubMed:)
  2. Boyault C et al. (2007) HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev, 21:2172-81. (PubMed:17785525)
  3. Boyault C et al. (2006) HDAC6-p97/VCP controlled polyubiquitin chain turnover. EMBO J, 25:3357-66. (PubMed:16810319)
  4. Fusco C et al. (2012) The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome. PLoS One, 7:e40440. (PubMed:22792322)
  5. Lafarga V et al. (2012) A novel GRK2/HDAC6 interaction modulates cell spreading and motility. EMBO J, 31:856-69. (PubMed:22193721)
  6. Matsuyama A et al. (2002) In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation. EMBO J, 21:6820-31. (PubMed:12486003)
  7. Seigneurin-Berny D et al. (2001) Identification of Components of the Murine Histone Deacetylase 6 Complex: Link between Acetylation and Ubiquitination Signaling Pathways. Mol Cell Biol, 21:8035-44. (PubMed:11689694)
  8. Southwood CM et al. (2007) Microtubule deacetylases, SirT2 and HDAC6, in the nervous system. Neurochem Res, 32:187-95. (PubMed:16933150)
  9. Verdel A et al. (1999) Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers. J Biol Chem, 274:2440-5. (PubMed:9891014)
  10. Wickstrom SA et al. (2010) CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin. EMBO J, 29:131-44. (PubMed:19893491)
  11. Zhang Y et al. (2003) HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. EMBO J, 22:1168-79. (PubMed:12606581)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory