Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Csrp3. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Csrp3
  • performs the following molecular functions:
    • actinin binding ^[4]
  • is located in the following cellular components:
    • Z disc ^[2]
• The gene product of Csrp3 has been shown to bind to the gene products of Glrx3, Ldhd. ^{[1, 3]} Researchers have inferred, based on physical interactions, that the gene product of Csrp3
  • performs the following molecular functions:
    • telethonin binding ^[4]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Csrp3
  • participates in the following biological processes:
    • cardiac muscle contraction ^[4]
    • cardiac myofibril assembly ^[4]
    • detection of muscle stretch ^[4]
    • protein localization to organelle ^[4]
  • performs the following molecular functions:
    • structural constituent of muscle ^[4]
• Researchers have inferred, based on genetic interactions, that the gene product of Csrp3
  • participates in the following biological processes:
    • cardiac muscle tissue development based on interactions with Pln ^[5]
    • cellular calcium ion homeostasis based on interactions with Pln ^[5]
    • regulation of the force of heart contraction based on interactions with Pln ^[5]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Csrp3:
  • participates in the following biological processes:
    • cardiac muscle contraction
    • cardiac muscle hypertrophy
    • detection of muscle stretch
    • protein localization to organelle
  • performs the following molecular functions:
    • structural constituent of muscle
    • telethonin binding
  • is located in the following cellular components:
    • cytoplasm
    • nucleus
    • Z disc

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Summary text based on GO annotations supported by structural data

• Csrp3 encodes a protein or proteins that contain the following InterPro domains: Zinc finger, LIM-type, indicating that the gene product:
  • performs the following molecular functions:
    • zinc ion binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Csrp3 indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • multicellular organismal development
    • muscle organ development
  • performs the following molecular functions:
    • metal ion binding
  • is located in the following cellular components:
    • cytoskeleton

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References

1. Flick MJ et al. (2002) Identification of putative mammalian D-lactate dehydrogenase enzymes. Biochem Biophys Res Commun, 295:910-6. (PubMed:12127981)
2. Heineke J et al. (2005) Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc. Proc Natl Acad Sci U S A, 102:1655-60. (PubMed:15665106)
3. Jeong D et al. (2008) PICOT attenuates cardiac hypertrophy by disrupting calcineurin-NFAT signaling. Circ Res, 102:711-9. (PubMed:18258855)
4. Knoll R et al. (2002) The Cardiac Mechanical Stretch Sensor Machinery Involves a Z Disc Complex that Is Defective in a Subset of Human Dilated Cardiomyopathy. Cell, 111:943-55. (PubMed:12507422)
5. Minamisawa S et al. (1999) Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell, 99:313-22. (PubMed:10555147)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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