Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and identical protein binding activity. Involved in several processes, including animal organ development; embryonic limb morphogenesis; and regulation of apoptotic process. Localizes to nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; sensory organ; and surface ectoderm. Used to study ankyloblepharon-ectodermal defects-cleft lip/palate syndrome; bladder exstrophy; ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3; and gastroesophageal reflux disease. Human ortholog(s) of this gene implicated in several diseases, including ADULT syndrome; EEC syndrome (multiple); ectodermal dysplasia (multiple); orofacial cleft 8; and split hand-foot malformation 4. Orthologous to human TP63 (tumor protein p63).