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Gene Ontology Classifications
transformation related protein 63

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Trp63. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of March 7, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

This gene encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include tumor proteins p53, p63, and p73, which have high sequence similarity to one another. This similarity allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways, including direct and indirect protein interactions. This results in mutual regulation of target gene promoters. Tumor protein p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Both alternative splicing and the use of alternative promoters result in multiple transcript variants encoding different protein isoforms.[provided by RefSeq, Dec 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Adorno M et al. (2009) A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis. Cell, 137:87-98. (PubMed:19345189)
  2. Antonini D et al. (2008) Tprg, a gene predominantly expressed in skin, is a direct target of the transcription factor p63. J Invest Dermatol, 128:1676-85. (PubMed:18256694)
  3. Birger Y et al. (2006) A role for chromosomal protein HMGN1 in corneal maturation. Differentiation, 74:19-29. (PubMed:16466397)
  4. Candi E et al. (2006) Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice. Cell Death Differ, 13:1037-47. (PubMed:16601749)
  5. Candi E et al. (2006) p63 is upstream of IKK alpha in epidermal development. J Cell Sci, 119:4617-22. (PubMed:17093266)
  6. Chae YS et al. (2012) Cell density-dependent acetylation of DeltaNp63alpha is associated with p53-dependent cell cycle arrest. FEBS Lett, 586:1128-34. (PubMed:22575646)
  7. Cheng W et al. (2006) DeltaNp63 plays an anti-apoptotic role in ventral bladder development. Development, 133:4783-92. (PubMed:17079275)
  8. Danielian PS et al. (2007) E2f4 is required for normal development of the airway epithelium. Dev Biol, 305:564-76. (PubMed:17383628)
  9. Daniely Y et al. (2004) Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium. Am J Physiol Cell Physiol, 287:C171-81. (PubMed:15189821)
  10. Deutsch GB et al. (2011) DNA damage in oocytes induces a switch of the quality control factor TAp63alpha from dimer to tetramer. Cell, 144:566-76. (PubMed:21335238)
  11. Fessing MY et al. (2011) p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis. J Cell Biol, 194:825-39. (PubMed:21930775)
  12. Gunschmann C et al. (2013) Insulin/IGF-1 Controls Epidermal Morphogenesis via Regulation of FoxO-Mediated p63 Inhibition. Dev Cell, 26:176-87. (PubMed:23906066)
  13. Ince TA et al. (2002) p63 Coordinates Anogenital Modeling and Epithelial Cell Differentiation in the Developing Female Urogenital Tract. Am J Pathol, 161:1111-7. (PubMed:12368184)
  14. Jacobs WB et al. (2005) p63 is an essential proapoptotic protein during neural development. Neuron, 48:743-56. (PubMed:16337913)
  15. Jheon AH et al. (2011) PERP regulates enamel formation via effects on cell-cell adhesion and gene expression. J Cell Sci, 124:745-54. (PubMed:21285247)
  16. Keyes WM et al. (2005) p63 deficiency activates a program of cellular senescence and leads to accelerated aging. Genes Dev, 19:1986-99. (PubMed:16107615)
  17. King KE et al. (2003) deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes. Oncogene, 22:3635-44. (PubMed:12789272)
  18. Koster MI et al. (2004) p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev, 18:126-31. (PubMed:14729569)
  19. Kulesz-Martin M et al. (2005) Melanocyte and keratinocyte carcinogenesis: p53 family protein activities and intersecting mRNA expression profiles. J Investig Dermatol Symp Proc, 10:142-52. (PubMed:16363065)
  20. Kurata S et al. (2004) p51/p63 Controls subunit alpha3 of the major epidermis integrin anchoring the stem cells to the niche. J Biol Chem, 279:50069-77. (PubMed:15361520)
  21. Kurita T et al. (2004) Role of p63 and basal cells in the prostate. Development, 131:4955-64. (PubMed:15371309)
  22. Laurikkala J et al. (2006) p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation. Development, 133:1553-63. (PubMed:16524929)
  23. Lee S et al. (2013) Forward genetics identifies Kdf1/1810019J16Rik as an essential regulator of the proliferation-differentiation decision in epidermal progenitor cells. Dev Biol, 383:201-13. (PubMed:24075906)
  24. Livera G et al. (2008) p63 null mutation protects mouse oocytes from radio-induced apoptosis. Reproduction, 135:3-12. (PubMed:18159078)
  25. Lo Iacono N et al. (2008) Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects. Development, 135:1377-88. (PubMed:18326838)
  26. Mills AA et al. (1999) p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature, 398:708-13. (PubMed:10227293)
  27. Nakamuta N et al. (2004) Expression of p63 in the mouse primordial germ cells. J Vet Med Sci, 66:1365-70. (PubMed:15585950)
  28. Nguyen BC et al. (2006) Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes Dev, 20:1028-42. (PubMed:16618808)
  29. Osada M et al. (2005) p63-Specific Activation of the BPAG-1e Promoter. J Invest Dermatol, 125:52-60. (PubMed:15982302)
  30. Patrick BA et al. (2011) Disruption of NAD(P)H:quinone oxidoreductase 1 gene in mice leads to 20S proteasomal degradation of p63 resulting in thinning of epithelium and chemical-induced skin cancer. Oncogene, 30:1098-107. (PubMed:21042282)
  31. Que J et al. (2007) Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development, 134:2521-31. (PubMed:17522155)
  32. Ramaesh T et al. (2005) Developmental and cellular factors underlying corneal epithelial dysgenesis in the Pax6(+/-) mouse model of aniridia. Exp Eye Res, 81:224-235. (PubMed:16080917)
  33. Richardson RJ et al. (2006) Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch. Nat Genet, 38:1329-34. (PubMed:17041603)
  34. Romano RA et al. (2012) DeltaNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation. Development, 139:772-82. (PubMed:22274697)
  35. Rufini A et al. (2006) p63 protein is essential for the embryonic development of vibrissae and teeth. Biochem Biophys Res Commun, 340:737-41. (PubMed:16410075)
  36. Shalom-Feuerstein R et al. (2011) DeltaNp63 is an ectodermal gatekeeper of epidermal morphogenesis. Cell Death Differ, 18:887-96. (PubMed:21127502)
  37. Signoretti S et al. (2000) p63 is a prostate basal cell marker and Is required for prostate development Am J Pathol, 157:1769-75. (PubMed:11106548)
  38. Simons AL et al. (2013) The Justy mutant mouse strain produces a spontaneous murine model of salivary gland cancer with myoepithelial and basal cell differentiation. Lab Invest, 93:711-9. (PubMed:23608756)
  39. Suh EK et al. (2006) p63 protects the female germ line during meiotic arrest. Nature, 444:624-8. (PubMed:17122775)
  40. Suliman Y et al. (2001) p63 expression is associated with p53 loss in oral-esophageal epithelia of p53-deficient mice. Cancer Res, 61:6467-73. (PubMed:11522642)
  41. Suzuki K et al. (2008) Abnormal urethra formation in mouse models of Split-hand/split-foot malformation type 1 and type 4. Eur J Hum Genet, 16:36-44. (PubMed:17878916)
  42. Wang N et al. (2010) Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress. EMBO Rep, 11:633-9. (PubMed:20559324)
  43. Yang A et al. (1999) p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature, 398:714-8. (PubMed:10227294)
  44. Yang A et al. (1998) p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell, 2:305-16. (PubMed:9774969)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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