Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Dpm1. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of September 4, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Dpm1
  • participates in the following biological processes:
    • dolichol metabolic process ^[1]
    • GPI anchor biosynthetic process ^[1]
  • performs the following molecular functions:
    • dolichyl-phosphate beta-D-mannosyltransferase activity ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Dpm1:
  • participates in the following biological processes:
    • dolichol metabolic process
    • GDP-mannose metabolic process
    • GPI anchor biosynthetic process
    • protein mannosylation
    • protein O-linked mannosylation
  • performs the following molecular functions:
    • alcohol binding
    • dolichyl-phosphate beta-D-mannosyltransferase activity
    • dolichyl-phosphate-mannose-protein mannosyltransferase activity
    • mannose binding
  • is located in the following cellular components:
    • dolichol-phosphate-mannose synthase complex
    • endoplasmic reticulum
    • endoplasmic reticulum membrane
    • intracellular membrane-bounded organelle
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Dpm1 indicates that it:
  • performs the following molecular functions:
    • transferase activity
    • transferase activity, transferring glycosyl groups

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References

1. Tomita S et al. (1998) A homologue of Saccharomyces cerevisiae Dpm1p is not sufficient for synthesis of dolichol-phosphate-mannose in mammalian cells. J Biol Chem, 273:9249-54. (PubMed:9535917)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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