Automated description from the Alliance of Genome Resources
Predicted to have chloride channel activity and voltage-gated ion channel activity. Involved in regulation of body fluid levels and renal inner medulla development. Localizes to the basolateral plasma membrane. Used to study nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in Bartter disease type 3; Bartter disease type 4b; Gitelman syndrome; hypertension; and sensorineural hearing loss. Is expressed in inner ear and metanephros. Orthologous to several human genes including CLCNKA (chloride voltage-gated channel Ka).