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Gene Ontology Classifications
Symbol
Name
ID
Cdk9
cyclin-dependent kinase 9 (CDC2-related kinase)
MGI:1328368

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cdk9. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Bezstarosti K et al. (2010) Differential proteomics based on 18O labeling to determine the cyclin dependent kinase 9 interactome. J Proteome Res, 9:4464-75. (PubMed:20593818)
  2. Gaucher J et al. (2012) Bromodomain-dependent stage-specific male genome programming by Brdt. EMBO J, 31:3809-20. (PubMed:22922464)
  3. Jang MK et al. (2005) The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. Mol Cell, 19:523-34. (PubMed:16109376)
  4. Ji X et al. (2013) SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase. Cell, 153:855-68. (PubMed:23663783)
  5. Okamura D et al. (2012) Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells. Genes Dev, 26:2477-82. (PubMed:23154982)
  6. Padmanabhan K et al. (2012) Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex. Science, 337:599-602. (PubMed:22767893)
  7. Proserpio V et al. (2013) The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy. Genes Dev, 27:1299-312. (PubMed:23752591)
  8. Rahl PB et al. (2010) c-Myc regulates transcriptional pause release. Cell, 141:432-45. (PubMed:20434984)
  9. Song SH et al. (2010) Multiple functions of Ldb1 required for beta-globin activation during erythroid differentiation. Blood, 116:2356-64. (PubMed:20570862)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory