Automated description from the Alliance of Genome Resources
Exhibits ATPase binding activity. Involved in several processes, including negative regulation of apoptotic process; protein stabilization; and ubiquitin-dependent ERAD pathway. Localizes to the endoplasmic reticulum. Predicted to colocalize with the proteasome complex. Used to study Wolfram syndrome 1. Human ortholog(s) of this gene implicated in Wolfram syndrome (multiple); auditory system disease (multiple); cataract 41; diabetes mellitus (multiple); and optic atrophy. Is expressed in several structures, including brain; craniocervical region bone; diaphragm; stomach; and vertebral axis musculature. Orthologous to human WFS1 (wolframin ER transmembrane glycoprotein).