Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits ATPase binding activity. Involved in several processes, including negative regulation of apoptotic process; protein stabilization; and ubiquitin-dependent ERAD pathway. Localizes to endoplasmic reticulum. Is expressed in several structures, including brain; craniocervical region bone; diaphragm; stomach; and vertebral axis musculature. Used to study Wolfram syndrome 1. Human ortholog(s) of this gene implicated in Wolfram syndrome (multiple); auditory system disease (multiple); cataract 41; diabetes mellitus (multiple); and optic atrophy (multiple). Orthologous to human WFS1 (wolframin ER transmembrane glycoprotein).