Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of St3gal4. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of St3gal4
  • participates in the following biological processes:
    • protein glycosylation ^[1]
  • performs the following molecular functions:
    • beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of St3gal4:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • monosialoganglioside sialyltransferase activity

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Summary text based on GO annotations supported by structural data

• St3gal4 encodes a protein or proteins that contain the following InterPro domains: Glycosyl transferase, family 29, Sialyltransferase, indicating that the gene product:
  • performs the following molecular functions:
    • sialyltransferase activity
  • is located in the following cellular components:
    • integral to Golgi membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe St3gal4 indicates that it:
  • performs the following molecular functions:
    • transferase activity
    • transferase activity, transferring glycosyl groups
  • is located in the following cellular components:
    • Golgi apparatus
    • integral to membrane
    • membrane

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References

1. Kono M et al. (1997) Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of in vitro substrate specificities and tissue specific expression. Glycobiology, 7:469-79. (PubMed:9184827)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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