Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cyba. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cyba
  • is located in the following cellular components:
    • cytoplasm ^[3]
    • mitochondrion ^[2]
• The gene product of Cyba has been shown to bind to the gene products of Sh3pxd2a. ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cyba:
  • participates in the following biological processes:
    • cellular response to organic substance
    • cytochrome complex assembly
    • hydrogen peroxide biosynthetic process
    • inflammatory response
    • innate immune response
    • negative regulation of glomerular filtration by angiotensin
    • oxidation-reduction process
    • positive regulation of cell growth
    • positive regulation of endothelial cell proliferation
    • regulation of blood pressure
    • respiratory burst
    • smooth muscle hypertrophy
    • superoxide anion generation
    • superoxide metabolic process
  • performs the following molecular functions:
    • electron carrier activity
    • protein heterodimerization activity
    • SH3 domain binding
    • superoxide-generating NADPH oxidase activity
  • is located in the following cellular components:
    • apical plasma membrane
    • dendrite
    • Golgi apparatus
    • NADPH oxidase complex
    • neuronal cell body
    • perinuclear endoplasmic reticulum

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Summary text based on GO annotations supported by structural data

• Cyba encodes a protein or proteins that contain the following InterPro domains: Cytochrome b558 alpha-subunit, indicating that the gene product:
  • performs the following molecular functions:
    • heme binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cyba indicates that it:
  • participates in the following biological processes:
    • electron transport chain
    • transport
  • performs the following molecular functions:
    • metal ion binding
    • oxidoreductase activity
  • is located in the following cellular components:
    • membrane
    • plasma membrane

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References

1. Diaz B et al. (2009) Tks5-dependent, nox-mediated generation of reactive oxygen species is necessary for invadopodia formation. Sci Signal, 2:ra53. (PubMed:19755709)
2. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
3. Shukla S et al. (2005) Identification of non-mitochondrial NADPH oxidase and the spatio-temporal organization of its components in mouse spermatozoa. Biochem Biophys Res Commun, 331:476-83. (PubMed:15850784)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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