Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables D-erythro-sphingosine kinase activity; acetyltransferase activity; and sphinganine kinase activity. Involved in several processes, including negative regulation of ceramide biosynthetic process; regulation of microglial cell activation; and regulation of vesicle-mediated transport. Acts upstream of or within several processes, including cellular response to hydrogen peroxide; positive regulation of mitotic nuclear division; and sphingolipid mediated signaling pathway. Located in endocytic vesicle; nucleus; and presynapse. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SPHK1 (sphingosine kinase 1).