Gene Ontology Classifications

Symbol
Name
ID

Tnfrsf1a
tumor necrosis factor receptor superfamily, member 1a
MGI:1314884

Go Annotations as Summary Text (Tabular View) (GO Graph)

Automated description from the Alliance of Genome Resources (Release 8.2.0)

Enables tumor necrosis factor receptor activity. Involved in several processes, including positive regulation of apoptotic process; regulation of lipid metabolic process; and semi-lunar valve development. Acts upstream of or within several processes, including intracellular signal transduction; positive regulation of transcription by RNA polymerase II; and regulation of signal transduction. Located in cell surface and membrane raft. Is active in plasma membrane. Is expressed in several structures, including extraembryonic component; genitourinary system; gut; hemolymphoid system; and nervous system. Used to study TNF receptorassociated periodic syndrome. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; TNF receptorassociated periodic syndrome; acne; allergic bronchopulmonary aspergillosis; and autoimmune disease (multiple). Orthologous to human TNFRSF1A (TNF receptor superfamily member 1A).

Go Annotations in Tabular Form (Text View) (GO Graph)

Aspect

Category

Evidence

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Filter

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24