Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits tumor necrosis factor-activated receptor activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of extracellular matrix constituent secretion; and semi-lunar valve development. Localizes to cell surface and membrane raft. Is expressed in several structures, including blood; dorsal aorta; extraembryonic component; lung; and reproductive system. Used to study autosomal dominant familial periodic fever. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; acne; allergic bronchopulmonary aspergillosis; autoimmune disease (multiple); and autosomal dominant familial periodic fever. Orthologous to human TNFRSF1A (TNF receptor superfamily member 1A).