Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Rasgrp1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Rasgrp1
  • participates in the following biological processes:
    • activation of Ras GTPase activity ^[1]
    • activation of Rho GTPase activity ^[1]
    • cytokine production ^[1]
    • inflammatory response to antigenic stimulus ^[1]
    • mast cell degranulation ^[1]
    • regulation of phosphatidylinositol 3-kinase cascade ^[1]
    • secretory granule localization ^[1]
    • vesicle transport along microtubule ^[1]

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Summary text based on GO annotations supported by structural data

• Rasgrp1 encodes a protein or proteins that contain the following InterPro domains: Diacylglycerol/phorbol-ester binding, EF-Hand 1, calcium-binding site, EF-HAND 2, EF-hand-like domain, Guanine-nucleotide dissociation stimulator CDC25, Protein kinase C-like, phorbol ester/diacylglycerol binding, Ras guanine nucleotide exchange factor, Ras guanine nucleotide exchange factor, domain, Ras-like guanine nucleotide exchange factor, N-terminal, indicating that the gene product:
  • participates in the following biological processes:
    • intracellular signal transduction
    • regulation of small GTPase mediated signal transduction
    • small GTPase mediated signal transduction
  • performs the following molecular functions:
    • calcium ion binding
    • guanyl-nucleotide exchange factor activity
  • is located in the following cellular components:
    • intracellular

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Rasgrp1 indicates that it:
  • participates in the following biological processes:
    • cell differentiation
  • performs the following molecular functions:
    • guanyl-nucleotide exchange factor activity
    • metal ion binding
  • is located in the following cellular components:
    • cytoplasm
    • endoplasmic reticulum
    • Golgi apparatus
    • membrane
    • plasma membrane

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References

1. Liu Y et al. (2007) An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response. J Exp Med, 204:93-103. (PubMed:17190838)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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