Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables chloride channel activity. Involved in renal absorption. Located in apicolateral plasma membrane and bicellular tight junction. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; salivary gland primordium; and sensory organ. Human ortholog(s) of this gene implicated in ovarian cancer and pancreatic cancer. Orthologous to human CLDN4 (claudin 4).