Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Fzd9. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of August 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Fzd9
  • is located in the following cellular components:
    • filopodium membrane ^[2]
    • perinuclear region of cytoplasm ^[2]
    • plasma membrane ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Fzd9
  • participates in the following biological processes:
    • B cell differentiation ^[1]
    • learning or memory ^[3]
    • neuroblast proliferation ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Fzd9:
  • participates in the following biological processes:
    • brain development
    • canonical Wnt receptor signaling pathway
    • embryo development
    • gonad development
    • regulation of transcription from RNA polymerase II promoter
    • vasculature development
    • Wnt receptor signaling pathway
  • performs the following molecular functions:
    • PDZ domain binding
    • protein heterodimerization activity
    • protein homodimerization activity
    • Wnt-activated receptor activity
    • Wnt-protein binding
  • is located in the following cellular components:
    • cell surface
    • cytoplasm
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Fzd9 encodes a protein or proteins that contain the following InterPro domains: Frizzled domain, Frizzled protein, Frizzled-9, Frizzled/secreted frizzled-related protein, GPCR, family 2-like, indicating that the gene product:
  • participates in the following biological processes:
    • cell surface receptor signaling pathway
  • performs the following molecular functions:
    • transmembrane signaling receptor activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Fzd9 indicates that it:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
    • multicellular organismal development
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Ranheim EA et al. (2005) Frizzled 9 knock-out mice have abnormal B-cell development. Blood, 105:2487-94. (PubMed:15572594)
2. Wang YK et al. (1999) Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome. Genomics, 57:235-48. (PubMed:10198163)
3. Zhao C et al. (2005) Hippocampal and visuospatial learning defects in mice with a deletion of frizzled 9, a gene in the Williams syndrome deletion interval. Development, 132:2917-27. (PubMed:15930120)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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