Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables calcium ion binding activity. Involved in regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion and sarcomere organization. Acts upstream of or within endoplasmic reticulum organization; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; and response to heat. Located in mitochondrial matrix and sarcoplasmic reticulum lumen. Is expressed in several structures, including diaphragm; lung; musculature; myotome; and sciatic nerve. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CASQ1 (calsequestrin 1).