Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Itgae. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Itgae
  • is located in the following cellular components:
    • external side of plasma membrane ^{[1, 2, 3]}

---

Summary text based on GO annotations supported by structural data

• Itgae encodes a protein or proteins that contain the following InterPro domains: FG-GAP repeat, Integrin alpha beta-propellor, Integrin alpha chain, Integrin alpha chain, C-terminal cytoplasmic region, conserved site, Integrin alpha-2, von Willebrand factor, type A, indicating that the gene product:
  • participates in the following biological processes:
    • cell adhesion
  • is located in the following cellular components:
    • integrin complex

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Itgae indicates that it:
  • participates in the following biological processes:
    • cell adhesion
    • integrin-mediated signaling pathway
  • performs the following molecular functions:
    • metal ion binding
  • is located in the following cellular components:
    • integral to membrane
    • membrane

---

References

1. Abe J et al. (2008) Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus. Am J Pathol, 173:1682-92. (PubMed:19008373)
2. Chae WJ et al. (2006) The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Proc Natl Acad Sci U S A, 103:9631-6. (PubMed:16769892)
3. Fontenot JD et al. (2005) A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol, 6:1142-51. (PubMed:16227984)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---