Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Naip1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Naip1
  • is located in the following cellular components:
    • basolateral plasma membrane ^[1]
    • cytoplasm ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Naip1
  • participates in the following biological processes:
    • cellular response to estrogen stimulus ^[2]
    • negative regulation of apoptotic process ^{[1, 2]}
    • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ^[1]
  • performs the following molecular functions:
    • cysteine-type endopeptidase inhibitor activity involved in apoptotic process ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Naip1:
  • participates in the following biological processes:
    • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
  • performs the following molecular functions:
    • ATP binding

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Summary text based on GO annotations supported by structural data

• Naip1 encodes a protein or proteins that contain the following InterPro domains: AAA+ ATPase domain, Baculoviral inhibition of apoptosis protein repeat, NACHT nucleoside triphosphatase, indicating that the gene product:
  • performs the following molecular functions:
    • nucleoside-triphosphatase activity
    • nucleotide binding
  • is located in the following cellular components:
    • intracellular

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Naip1 indicates that it:
  • participates in the following biological processes:
    • apoptotic process
    • negative regulation of peptidase activity
  • performs the following molecular functions:
    • cysteine-type endopeptidase inhibitor activity
    • metal ion binding
    • nucleotide binding
    • peptidase inhibitor activity

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References

1. Dziarmaga A et al. (2006) Neuronal apoptosis inhibitory protein is expressed in developing kidney and is regulated by PAX2. Am J Physiol Renal Physiol, 291:F913-20. (PubMed:16735463)
2. Yin Y et al. (2008) Estrogen suppresses uterine epithelial apoptosis by inducing birc1 expression. Mol Endocrinol, 22:113-25. (PubMed:17901126)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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