Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Gpd1l. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene catalyzes the conversion of sn-glycerol 3-phosphate to glycerone phosphate. The encoded protein is found in the cytoplasm, associated with the plasma membrane, where it binds the sodium channel, voltage-gated, type V, alpha subunit (SCN5A). Defects in this gene are a cause of Brugada syndrome type 2 (BRS2) as well as sudden infant death syndrome (SIDS). [provided by RefSeq, Jul 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Gpd1l
  • participates in the following biological processes:
    • NADH metabolic process ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Gpd1l:
  • participates in the following biological processes:
    • NAD metabolic process
    • negative regulation of peptidyl-serine phosphorylation
    • negative regulation of protein kinase C signaling cascade
    • positive regulation of protein localization to cell surface
    • positive regulation of sodium ion transport
    • regulation of heart rate
    • regulation of sodium ion transmembrane transporter activity
    • regulation of ventricular cardiac muscle cell action potential
    • regulation of ventricular cardiac muscle cell membrane depolarization
  • performs the following molecular functions:
    • ion channel binding
    • sodium channel regulator activity
  • is located in the following cellular components:
    • cytoplasm
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Gpd1l encodes a protein or proteins that contain the following InterPro domains: 6-phosphogluconate dehydrogenase, C-terminal-like, Dehydrogenase, multihelical, Glycerol-3-phosphate dehydrogenase, NAD-dependent, Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal, Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryotic, Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal, NAD(P)-binding domain, indicating that the gene product:
  • participates in the following biological processes:
    • carbohydrate metabolic process
    • glycerol-3-phosphate catabolic process
    • glycerol-3-phosphate metabolic process
    • oxidation-reduction process
  • performs the following molecular functions:
    • coenzyme binding
    • glycerol-3-phosphate dehydrogenase [NAD+] activity
    • NAD binding
    • nucleotide binding
    • oxidoreductase activity
    • oxidoreductase activity, acting on CH-OH group of donors
    • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    • protein homodimerization activity
  • is located in the following cellular components:
    • glycerol-3-phosphate dehydrogenase complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Gpd1l indicates that it:
  • participates in the following biological processes:
    • oxidation-reduction process
  • performs the following molecular functions:
    • oxidoreductase activity
• Gpd1l has been associated with the Enzyme Commission numbers: 1.1.1.8, which implies that the gene product:
  • performs the following molecular functions:
    • glycerol-3-phosphate dehydrogenase [NAD+] activity

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References

1. Liu M et al. (2009) Cardiac Na+ current regulation by pyridine nucleotides. Circ Res, 105:737-45. (PubMed:19745168)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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