Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cdkl5. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cdkl5:
  • participates in the following biological processes:
    • neuron migration
    • positive regulation of axon extension
    • positive regulation of dendrite morphogenesis
    • positive regulation of Rac GTPase activity
    • protein autophosphorylation
    • regulation of dendrite development
  • performs the following molecular functions:
    • ATP binding
    • kinase activity
    • protein kinase activity
    • Rac GTPase binding
  • is located in the following cellular components:
    • cytoplasm
    • dendrite cytoplasm
    • dendritic growth cone
    • nucleus
    • ruffle membrane

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Summary text based on GO annotations supported by structural data

• Cdkl5 encodes a protein or proteins that contain the following InterPro domains: Protein kinase, ATP binding site, Protein kinase, catalytic domain, Protein kinase-like domain, Serine/threonine- / dual specificity protein kinase, catalytic domain, Serine/threonine-protein kinase, active site, indicating that the gene product:
  • participates in the following biological processes:
    • protein phosphorylation
  • performs the following molecular functions:
    • protein serine/threonine kinase activity
    • transferase activity, transferring phosphorus-containing groups

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cdkl5 indicates that it:
  • participates in the following biological processes:
    • phosphorylation
  • performs the following molecular functions:
    • nucleotide binding
    • protein serine/threonine kinase activity
    • transferase activity
• Cdkl5 has been associated with the Enzyme Commission numbers: 2.7.11.22, which implies that the gene product:
  • performs the following molecular functions:
    • cyclin-dependent protein serine/threonine kinase activity

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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