Automated description from the Alliance of Genome Resources
Exhibits ubiquitin-protein transferase activity. Involved in ubiquitin-dependent protein catabolic process. Localizes to the proteasome complex and ubiquitin ligase complex. Used to study Johanson-Blizzard syndrome. Human ortholog(s) of this gene implicated in Johanson-Blizzard syndrome. Orthologous to human UBR1 (ubiquitin protein ligase E3 component n-recognin 1).