Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits ionotropic glutamate receptor binding activity and scaffold protein binding activity. Involved in several processes, including dendritic spine morphogenesis; locomotory exploration behavior; and regulation of grooming behavior. Localizes to several cellular components, including AMPA glutamate receptor complex; axon; and extrinsic component of cytoplasmic side of plasma membrane. Colocalizes with ionotropic glutamate receptor complex and postsynaptic membrane. Is expressed in central nervous system; dorsal root ganglion; olfactory epithelium; and retina. Used to study Williams-Beuren syndrome and autism spectrum disorder. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human DLG4 (discs large MAGUK scaffold protein 4).