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Gene Ontology Classifications
discs, large homolog 4 (Drosophila)

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Dlg4. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
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  10. Cook D et al. (2011) Fragile X related protein 1 clusters with ribosomes and messenger RNAs at a subset of dendritic spines in the mouse hippocampus. PLoS One, 6:e26120. (PubMed:22022532)
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  18. Gotthardt M et al. (2000) Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction. J Biol Chem, 275:25616-24. (PubMed:10827173)
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  20. Hawasli AH et al. (2007) Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation. Nat Neurosci, 10:880-6. (PubMed:17529984)
  21. Hering H et al. (2002) Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95. FEBS Lett, 521:185-9. (PubMed:12067714)
  22. Hoe HS et al. (2006) Apolipoprotein E receptor 2 interactions with the N-methyl-D-aspartate receptor. J Biol Chem, 281:3425-31. (PubMed:16332682)
  23. Horresh I et al. (2008) Multiple molecular interactions determine the clustering of Caspr2 and Kv1 channels in myelinated axons. J Neurosci, 28:14213-22. (PubMed:19109503)
  24. Hung AY et al. (2008) Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1. J Neurosci, 28:1697-708. (PubMed:18272690)
  25. Husi H et al. (2000) Proteomic analysis of NMDA receptor-adhesion protein signaling complexes [see comments] Nat Neurosci, 3:661-9. (PubMed:10862698)
  26. Ikeda A et al. (2002) Microtubule-associated protein 1A is a modifier of tubby hearing (moth1). Nat Genet, 30:401-5. (PubMed:11925566)
  27. Jellali A et al. (2002) Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina. J Comp Neurol, 449:76-87. (PubMed:12115694)
  28. Junghans D et al. (2008) Postsynaptic and differential localization to neuronal subtypes of protocadherin beta16 in the mammalian central nervous system. Eur J Neurosci, 27:559-71. (PubMed:18279309)
  29. Jurado S et al. (2013) LTP requires a unique postsynaptic SNARE fusion machinery. Neuron, 77:542-58. (PubMed:23395379)
  30. Kerrisk ME et al. (2013) Integrin alpha3 is required for late postnatal stability of dendrite arbors, dendritic spines and synapses, and mouse behavior. J Neurosci, 33:6742-52. (PubMed:23595732)
  31. Khalili K et al. (2003) Puralpha is essential for postnatal brain development and developmentally coupled cellular proliferation as revealed by genetic inactivation in the mouse. Mol Cell Biol, 23:6857-75. (PubMed:12972605)
  32. Kim S et al. (2006) NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formation. Nat Neurosci, 9:1294-301. (PubMed:16980967)
  33. Klemmer P et al. (2009) Proteomics analysis of immuno-precipitated synaptic protein complexes. J Proteomics, 72:82-90. (PubMed:19022416)
  34. Kohr G et al. (2003) Intracellular domains of NMDA receptor subtypes are determinants for long-term potentiation induction. J Neurosci, 23:10791-9. (PubMed:14645471)
  35. Komiyama NH et al. (2002) SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor. J Neurosci, 22:9721-32. (PubMed:12427827)
  36. Kurschner C et al. (1998) CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins. Mol Cell Neurosci, 11:161-72. (PubMed:9647694)
  37. Lai C et al. (2006) Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking. J Neurosci, 26:11798-806. (PubMed:17093100)
  38. Marschang P et al. (2004) Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1. Mol Cell Biol, 24:3782-93. (PubMed:15082773)
  39. Miyazaki T et al. (2006) Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family. FEBS Lett, 580:4057-64. (PubMed:16814779)
  40. Munton RP et al. (2007) Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol Cell Proteomics, 6:283-93. (PubMed:17114649)
  41. Nakanishi N et al. (2013) Synaptic protein alpha1-takusan mitigates amyloid-beta-induced synaptic loss via interaction with tau and postsynaptic density-95 at postsynaptic sites. J Neurosci, 33:14170-83. (PubMed:23986251)
  42. Nakazawa T et al. (2006) NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. EMBO J, 25:2867-77. (PubMed:16710293)
  43. Ng D et al. (2009) Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning. PLoS Biol, 7:e41. (PubMed:19243221)
  44. Offenhauser N et al. (2006) Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics. Cell, 127:213-26. (PubMed:17018287)
  45. Ouyang Q et al. (2013) Christianson Syndrome Protein NHE6 Modulates TrkB Endosomal Signaling Required for Neuronal Circuit Development. Neuron, 80:97-112. (PubMed:24035762)
  46. Parisiadou L et al. (2014) LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity. Nat Neurosci, 17:367-76. (PubMed:24464040)
  47. Pham E et al. (2010) Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins. FEBS J, 277:3051-67. (PubMed:20573181)
  48. Schultze W et al. (2001) Semaphorin4F interacts with the synapse-associated protein SAP90/PSD-95. J Neurochem, 78:482-9. (PubMed:11483650)
  49. Schwenk J et al. (2012) High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes. Neuron, 74:621-33. (PubMed:22632720)
  50. Shimokawa N et al. (2010) CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice. EMBO J, 29:2421-32. (PubMed:20551902)
  51. Sprengel R et al. (1998) Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. Cell, 92:279-89. (PubMed:9458051)
  52. Stohr H et al. (2009) TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals. J Neurosci, 29:6809-18. (PubMed:19474308)
  53. Trinidad JC et al. (2005) Phosphorylation state of postsynaptic density proteins. J Neurochem, 92:1306-16. (PubMed:15748150)
  54. Tsai NP et al. (2012) Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95. Cell, 151:1581-94. (PubMed:23260144)
  55. Tu W et al. (2010) DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke. Cell, 140:222-34. (PubMed:20141836)
  56. Uchino S et al. (2006) Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor. J Neurochem, 97:1203-14. (PubMed:16606358)
  57. Uemura T et al. (2004) Direct interaction of GluRdelta2 with Shank scaffold proteins in cerebellar Purkinje cells. Mol Cell Neurosci, 26:330-41. (PubMed:15207857)
  58. Van Campenhout CA et al. (2011) Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases. Dev Cell, 21:479-91. (PubMed:21920314)
  59. Wang CY et al. (2006) A novel family of adhesion-like molecules that interacts with the NMDA receptor. J Neurosci, 26:2174-83. (PubMed:16495444)
  60. Wentzel C et al. (2013) mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking. Neuron, 78:1012-23. (PubMed:23791195)
  61. Zha XM et al. (2009) ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95. J Neurosci, 29:8438-46. (PubMed:19571134)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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