Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Rp2h. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The RP2 locus has been implicated as one cause of X-linked retinitis pigmentosa. The predicted gene product shows homology with human cofactor C, a protein involved in the ultimate step of beta-tubulin folding. Progressive retinal degeneration may therefore be due to the accumulation of incorrectly-folded photoreceptor or neuron-specific tubulin isoforms followed by progressive cell death [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Rp2h:
  • participates in the following biological processes:
    • positive regulation of GTPase activity
  • performs the following molecular functions:
    • GTPase activator activity
  • is located in the following cellular components:
    • cytoplasm
    • plasma membrane

---

Summary text based on GO annotations supported by structural data

• Rp2h encodes a protein or proteins that contain the following InterPro domains: C-CAP/cofactor C-like domain, CARP motif, Nucleoside diphosphate kinase, Protein XRP2, Tubulin binding cofactor C, indicating that the gene product:
  • participates in the following biological processes:
    • CTP biosynthetic process
    • GTP biosynthetic process
    • nucleoside diphosphate phosphorylation
    • UTP biosynthetic process
  • performs the following molecular functions:
    • ATP binding
    • nucleoside diphosphate kinase activity

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Rp2h indicates that it:
  • participates in the following biological processes:
    • protein transport
    • transport
  • performs the following molecular functions:
    • GTP binding
    • nucleotide binding
  • is located in the following cellular components:
    • cell projection
    • cilium
    • membrane

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---