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Gene Ontology Classifications
Symbol
Name
ID
Dcx
doublecortin
MGI:1277171

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GO curators for mouse genes have assigned the following annotations to the gene product of Dcx. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq


This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase. Studies in knockout mice lacking this gene and the LIS1 gene suggest that the molecular interaction of these two genes is important in both in neuronal migration and neurogenesis, and there is a cortical role of this gene in nuclear translocation and positioning of the mitotic spindle in radial glial mitotic division. Multiple transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
References
  1. Deuel TA et al. (2006) Genetic interactions between doublecortin and doublecortin-like kinase in neuronal migration and axon outgrowth. Neuron, 49:41-53. (PubMed:16387638)
  2. Huang W et al. (2014) Protein kinase LKB1 regulates polarized dendrite formation of adult hippocampal newborn neurons. Proc Natl Acad Sci U S A, 111:469-74. (PubMed:24367100)
  3. Koizumi H et al. (2006) Doublecortin-like kinase functions with doublecortin to mediate fiber tract decussation and neuronal migration. Neuron, 49:55-66. (PubMed:16387639)
  4. Shimozaki K et al. (2013) Paired related homeobox protein 1 is a regulator of stemness in adult neural stem/progenitor cells. J Neurosci, 33:4066-75. (PubMed:23447615)
  5. Stegeman S et al. (2013) Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFbeta-mediated axonogenesis. PLoS One, 8:e68287. (PubMed:23861879)
  6. Tsukada M et al. (2003) Identification of neurabin II as a novel doublecortin interacting protein. Mech Dev, 120:1033-43. (PubMed:14550532)
  7. Wang Y et al. (2011) Dcdc2 knockout mice display exacerbated developmental disruptions following knockdown of doublecortin. Neuroscience, 190:398-408. (PubMed:21689730)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement

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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory