Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Dcx. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase. Studies in knockout mice lacking this gene and the LIS1 gene suggest that the molecular interaction of these two genes is important in both in neuronal migration and neurogenesis, and there is a cortical role of this gene in nuclear translocation and positioning of the mitotic spindle in radial glial mitotic division. Multiple transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Dcx
  • is located in the following cellular components:
    • intracellular ^[1]
• Researchers have inferred, based on genetic interactions, that the gene product of Dcx
  • participates in the following biological processes:
    • axon extension based on interactions with Dclk1 ^[2]
    • brain development based on interactions with Dclk1 ^[2]
    • central nervous system projection neuron axonogenesis based on interactions with Dclk1 ^[2]
    • dendrite morphogenesis based on interactions with Dcdc2a, Dclk1 ^{[2, 5]}
    • neuron migration based on interactions with Dcdc2a, Dclk1 ^{[2, 3, 5]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Dcx:
  • participates in the following biological processes:
    • neuron migration
  • performs the following molecular functions:
    • microtubule binding
    • protein kinase binding
  • is located in the following cellular components:
    • dendrite
    • neuron projection

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Summary text based on GO annotations supported by structural data

• Dcx encodes a protein or proteins that contain the following InterPro domains: Doublecortin domain, Neuronal migration protein doublecortin, chordata, indicating that the gene product:
  • participates in the following biological processes:
    • intracellular signal transduction

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Dcx indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • multicellular organismal development
    • nervous system development
  • is located in the following cellular components:
    • cell projection
    • cytoplasm
    • microtubule

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References

1. Cappello S et al. (2006) The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat Neurosci, 9:1099-107. (PubMed:16892058)
2. Deuel TA et al. (2006) Genetic interactions between doublecortin and doublecortin-like kinase in neuronal migration and axon outgrowth. Neuron, 49:41-53. (PubMed:16387638)
3. Koizumi H et al. (2006) Doublecortin-like kinase functions with doublecortin to mediate fiber tract decussation and neuronal migration. Neuron, 49:55-66. (PubMed:16387639)
4. Tsukada M et al. (2003) Identification of neurabin II as a novel doublecortin interacting protein. Mech Dev, 120:1033-43. (PubMed:14550532)
5. Wang Y et al. (2011) Dcdc2 knockout mice display exacerbated developmental disruptions following knockdown of doublecortin. Neuroscience, 190:398-408. (PubMed:21689730)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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