Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits chromatin binding activity; histone-lysine N-methyltransferase activity; and sequence-specific DNA binding activity. Involved in several processes, including cardiac septum morphogenesis; histone lysine methylation; and regulation of nucleobase-containing compound metabolic process. Localizes to nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study Wolf-Hirschhorn syndrome. Human ortholog(s) of this gene implicated in Wolf-Hirschhorn syndrome. Orthologous to human NSD2 (nuclear receptor binding SET domain protein 2).