Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits several functions, including histone-lysine N-methyltransferase activity; nuclear hormone receptor binding activity; and transcription corepressor activity. Involved in gastrulation with mouth forming second; histone methylation; and negative regulation of transcription by RNA polymerase II. Localizes to nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; ear; genitourinary system; and retina. Human ortholog(s) of this gene implicated in Sotos syndrome; acute myeloid leukemia; microcephaly; and neuroblastoma. Orthologous to human NSD1 (nuclear receptor binding SET domain protein 1).