Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Gpr98. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of June 1, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the G-protein coupled receptor superfamily. The encoded protein contains a 7-transmembrane receptor domain, binds calcium and is expressed in the central nervous system. Mutations in this gene are associated with Usher syndrome 2 and familial febrile seizures. Several alternatively spliced transcripts have been described. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Gpr98
  • is located in the following cellular components:
    • plasma membrane ^[3]
    • stereocilia ankle link complex ^[4]
• Researchers have inferred, based on physical interactions, that the gene product of Gpr98
  • performs the following molecular functions:
    • myosin binding ^[4]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Gpr98
  • participates in the following biological processes:
    • detection of mechanical stimulus involved in sensory perception of sound ^[3]
    • inner ear development ^[3]
    • inner ear receptor stereocilium organization ^[4]
    • neurological system process ^[6]
    • sensory perception of sound ^{[1, 2, 5]}
    • visual perception ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Gpr98:
  • participates in the following biological processes:
    • maintenance of organ identity
    • neurological system process
    • photoreceptor cell maintenance
    • sensory perception of light stimulus
    • sensory perception of sound
  • performs the following molecular functions:
    • calcium ion binding
  • is located in the following cellular components:
    • cell surface
    • cytoplasm

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Summary text based on GO annotations supported by structural data

• Gpr98 encodes a protein or proteins that contain the following InterPro domains: Concanavalin A-like lectin/glucanase, subgroup, Concanavalin A-like lectin/glucanases superfamily, EAR, GPCR, family 2, secretin-like, GPCR, family 2-like, GPS domain, Leucine-rich glioma-inactivated , EPTP repeat, Na-Ca exchanger/integrin-beta4, indicating that the gene product:
  • participates in the following biological processes:
    • cell communication
    • cell surface receptor signaling pathway
    • neuropeptide signaling pathway
  • performs the following molecular functions:
    • transmembrane signaling receptor activity
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Gpr98 indicates that it:
  • participates in the following biological processes:
    • multicellular organismal development
    • response to stimulus
    • signal transduction
  • performs the following molecular functions:
    • signal transducer activity
  • is located in the following cellular components:
    • extracellular region
    • integral to membrane

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References

1. Johnson KR et al. (2005) The Mass1(frings) mutation underlies early onset hearing impairment in BUB/BnJ mice, a model for the auditory pathology of Usher syndrome IIC. Genomics, 85:582-90. (PubMed:15820310)
2. Klein BD et al. (2005) Auditory deficits associated with the frings mgr1 (mass1) mutation in mice. Dev Neurosci, 27:321-32. (PubMed:16137990)
3. McGee J et al. (2006) The very large G-protein-coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles. J Neurosci, 26:6543-53. (PubMed:16775142)
4. Michalski N et al. (2007) Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning. J Neurosci, 27:6478-88. (PubMed:17567809)
5. Schwander M et al. (2007) A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function. J Neurosci, 27:2163-75. (PubMed:17329413)
6. Skradski SL et al. (2001) A novel gene causing a mendelian audiogenic mouse epilepsy. Neuron, 31:537-44. (PubMed:11545713)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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