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Gene Ontology Classifications

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GO curators for mouse genes have assigned the following annotations to the gene product of Gck. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of October 29, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Aizawa T et al. (1996) Analysis of the pancreatic beta cell in the mouse with targeted disruption of the pancreatic beta cell-specific glucokinase gene. Biochem Biophys Res Commun, 229:460-5. (PubMed:8954920)
  2. Bali D et al. (1995) Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene. J Biol Chem, 270:21464-7. (PubMed:7665557)
  3. Coleman DL. (1977) Genetic control of glucokinase activity in mice. Biochem Genet, 15:297-305. (PubMed:141272)
  4. Danial NN et al. (2003) BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature, 424:952-6. (PubMed:12931191)
  5. Danial NN et al. (2008) Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med, 14:144-53. (PubMed:18223655)
  6. Efrat S et al. (1994) Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion. Proc Natl Acad Sci U S A, 91:2051-5. (PubMed:7510884)
  7. Goldsworthy M et al. (2008) Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance. Diabetes, 57:2234-44. (PubMed:18477811)
  8. Grimsby J et al. (2000) Characterization of glucokinase regulatory protein-deficient mice. J Biol Chem, 275:7826-31. (PubMed:10713097)
  9. Grupe A et al. (1995) Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis. Cell, 83:69-78. (PubMed:7553875)
  10. Hofmeister-Brix A et al. (2013) Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partner. J Biol Chem, 288:35824-39. (PubMed:24187134)
  11. Ishihara H et al. (1995) Inhibition of pancreatic beta-cell glucokinase by antisense RNA expression in transgenic mice: mouse strain-dependent alteration of glucose tolerance. FEBS Lett, 371:329-32. (PubMed:7556622)
  12. James PA et al. (1985) Comparison of glucokinase in C3H/He and C58 mice that differ in their hepatic activity. Biochem Genet, 23:525-38. (PubMed:3931624)
  13. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
  14. Piston DW et al. (1999) Adenovirus-mediated knockout of a conditional glucokinase gene in isolated pancreatic islets reveals an essential role for proximal metabolic coupling events in glucose-stimulated insulin secretion. J Biol Chem, 274:1000-4. (PubMed:9873043)
  15. Postic C et al. (1999) Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem, 274:305-15. (PubMed:9867845)
  16. Rossetti L et al. (1997) Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele. Am J Physiol, 273:E743-50. (PubMed:9357804)
  17. Sakura H et al. (1998) Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice. Diabetologia, 41:654-9. (PubMed:9662046)
  18. Terauchi Y et al. (1995) Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose. J Biol Chem, 270:30253-6. (PubMed:8530440)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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