Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits glucokinase activity. Involved in several processes, including calcium ion import; cellular glucose homeostasis; and positive regulation of insulin secretion. Localizes to cytosol; mitochondrion; and nucleus. Predicted to colocalize with actin filament. Is expressed in several structures, including alimentary system; brain; genitourinary system; musculoskeletal system; and sensory organ. Used to study hyperinsulinemic hypoglycemia; maturity-onset diabetes of the young type 2; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in artery disease (multiple); familial hyperinsulinemic hypoglycemia 3; and glucose metabolism disease (multiple). Orthologous to human GCK (glucokinase).