Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Vrk1. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Vrk1
  • participates in the following biological processes:
    • protein autophosphorylation ^[1]
    • protein phosphorylation ^[1]
  • performs the following molecular functions:
    • protein serine/threonine kinase activity ^[1]
  • is located in the following cellular components:
    • nucleus ^[1]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Vrk1:
  • participates in the following biological processes:
    • Golgi disassembly
    • protein autophosphorylation
  • performs the following molecular functions:
    • identical protein binding
    • protein serine/threonine kinase activity
  • is located in the following cellular components:
    • cytoplasm
    • Golgi stack
    • nucleolus
    • nucleus

---

Summary text based on GO annotations supported by structural data

• Vrk1 encodes a protein or proteins that contain the following InterPro domains: Protein kinase, ATP binding site, Protein kinase, catalytic domain, Protein kinase-like domain, Serine/threonine-protein kinase, active site, indicating that the gene product:
  • participates in the following biological processes:
    • protein phosphorylation
  • performs the following molecular functions:
    • ATP binding
    • protein kinase activity
    • transferase activity, transferring phosphorus-containing groups

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Vrk1 indicates that it:
  • participates in the following biological processes:
    • cell cycle
    • cell division
    • mitosis
    • phosphorylation
  • performs the following molecular functions:
    • ATP binding
    • kinase activity
    • nucleotide binding
    • transferase activity
  • is located in the following cellular components:
    • cytoskeleton

---

References

1. Nichols RJ et al. (2004) Characterization of three paralogous members of the Mammalian vaccinia related kinase family. J Biol Chem, 279:7934-46. (PubMed:14645249)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---