Automated description from the Alliance of Genome Resources (Release 8.1.0)
Enables DNA binding activity; S-adenosylmethionine-dependent methyltransferase activity; and lncRNA binding activity. Involved in autosome genomic imprinting; negative regulation of gene expression via chromosomal CpG island methylation; and transposable element silencing by piRNA-mediated DNA methylation. Acts upstream of or within several processes, including cellular response to bisphenol A; epigenetic regulation of gene expression; and oocyte development. Located in chromosome; cytoplasm; and nucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; limb mesenchyme; and sensory organ. Human ortholog(s) of this gene implicated in Tatton-Brown-Rahman syndrome; hematologic cancer (multiple); and stomach cancer. Orthologous to human DNMT3A (DNA methyltransferase 3 alpha).
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