Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits DNA (cytosine-5-)-methyltransferase activity; DNA binding activity; and chromatin binding activity. Involved in several processes, including DNA methylation; regulation of gene expression by genetic imprinting; and regulation of nucleobase-containing compound metabolic process. Localizes to chromosome and cytoplasm. Is expressed in several structures, including brain; early conceptus; reproductive system; sensory organ; and urethra. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; acute lymphoblastic leukemia; acute myeloid leukemia; myelodysplastic syndrome; and stomach cancer. Orthologous to human DNMT3A (DNA methyltransferase 3 alpha).