Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables DNA binding activity; S-adenosylmethionine-dependent methyltransferase activity; and chromatin binding activity. Involved in autosome genomic imprinting; negative regulation of gene expression via CpG island methylation; and post-fertilization epigenetic regulation of gene expression. Acts upstream of or within several processes, including cellular response to bisphenol A; epigenetic regulation of gene expression; and negative regulation of transcription by RNA polymerase II. Located in chromosome; cytoplasm; and nucleus. Part of heterochromatin. Is expressed in several structures, including brain; early conceptus; genitourinary system; limb mesenchyme; and sensory organ. Human ortholog(s) of this gene implicated in Tatton-Brown-Rahman syndrome; hematologic cancer (multiple); and stomach cancer. Orthologous to human DNMT3A (DNA methyltransferase 3 alpha).