Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Myo15. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Myo15
  • is located in the following cellular components:
    • stereocilium ^[5]
    • stereocilium bundle ^[5]
• The gene product of Myo15 has been shown to bind to the gene products of Whrn. ^{[1, 3]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Myo15
  • participates in the following biological processes:
    • inner ear morphogenesis ^{[4, 6]}
    • locomotory behavior ^[2]
    • sensory perception of sound ^{[4, 6]}

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Summary text based on GO annotations supported by structural data

• Myo15 encodes a protein or proteins that contain the following InterPro domains: Band 4.1 domain, FERM central domain, FERM domain, IQ motif, EF-hand binding site, Myosin head, motor domain, MyTH4 domain, Src homology-3 domain, Variant SH3, indicating that the gene product:
  • performs the following molecular functions:
    • ATP binding
    • motor activity
  • is located in the following cellular components:
    • cytoskeleton
    • myosin complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Myo15 indicates that it:
  • performs the following molecular functions:
    • actin binding
    • ATP binding
    • nucleotide binding
  • is located in the following cellular components:
    • cell projection
    • cytoplasm
    • cytoskeleton
    • myosin complex

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References

1. Belyantseva IA et al. (2005) Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia. Nat Cell Biol, 7:148-56. (PubMed:15654330)
2. Calderon A et al. (2006) Cochlear developmental defect and background-dependent hearing thresholds in the Jackson circler (jc) mutant mouse. Hear Res, 221:44-58. (PubMed:16962269)
3. Delprat B et al. (2005) Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly. Hum Mol Genet, 14:401-10. (PubMed:15590698)
4. Erichsen S et al. (2001) Cochlear distribution of Na,K-ATPase and corticosteroid receptors in two mouse strains with congenital hearing disorders. Acta Otolaryngol, 121:794-802. (PubMed:11718241)
5. Grimsley-Myers CM et al. (2009) The small GTPase Rac1 regulates auditory hair cell morphogenesis. J Neurosci, 29:15859-69. (PubMed:20016102)
6. Lee DJ et al. (2003) Effects of congenital deafness in the cochlear nuclei of Shaker-2 mice: an ultrastructural analysis of synapse morphology in the endbulbs of Held. J Neurocytol, 32:229-43. (PubMed:14724386)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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