Automated description from the Alliance of Genome Resources (Release 4.1.0)
Enables cysteine-type endopeptidase activity involved in apoptotic process. Involved in several processes, including negative regulation of necroptotic process; proteolysis; and pyroptosis. Acts upstream of or within several processes, including hepatocyte apoptotic process; regulation of apoptotic process; and tube morphogenesis. Located in cytoplasm; nucleus; and plasma membrane. Part of Noc1p-Noc2p complex. Is expressed in several structures, including brain; early conceptus; gonad; hemolymphoid system; and limb ectoderm. Used to study atopic dermatitis and autoimmune lymphoproliferative syndrome type 2B. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 2B; breast cancer; endocrine gland cancer (multiple); esophagus adenocarcinoma; and primary immunodeficiency disease. Orthologous to human CASP8 (caspase 8).