Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources

Exhibits 1-phosphatidylinositol-3-kinase activity; insulin receptor substrate binding activity; and protein kinase activator activity. Involved in several processes, including energy homeostasis; negative regulation of apoptotic process; and regulation of nucleobase-containing compound metabolic process. Localizes to the lamellipodium and phosphatidylinositol 3-kinase complex. Used to study CLOVES syndrome and breast cancer. Human ortholog(s) of this gene implicated in several diseases, including CLOVES syndrome; Cowden syndrome; breast cancer (multiple); carcinoma (multiple); and epidermal nevus. Is expressed in several structures, including early embryo; eye; and nervous system. Orthologous to human PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha).

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Gene Ontology Evidence Code Abbreviations:

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