Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Sorl1. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.[provided by RefSeq, Sep 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• The gene product of Sorl1 has been shown to bind to the gene products of Lrp1, Lrp2, Lrp4. ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Sorl1:
  • performs the following molecular functions:
    • low-density lipoprotein particle binding
  • is located in the following cellular components:
    • perinuclear region of cytoplasm

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Summary text based on GO annotations supported by structural data

• Sorl1 encodes a protein or proteins that contain the following InterPro domains: Fibronectin, type III, Immunoglobulin-like fold, LDLR class B repeat, Low-density lipoprotein (LDL) receptor class A repeat, Low-density lipoprotein (LDL) receptor class A, conserved site, Six-bladed beta-propeller, TolB-like, VPS10, indicating that the gene product:
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Sorl1 indicates that it:
  • participates in the following biological processes:
    • cholesterol metabolic process
    • endocytosis
    • lipid metabolic process
    • lipid transport
    • multicellular organismal development
    • steroid metabolic process
    • transport
  • is located in the following cellular components:
    • integral to membrane
    • low-density lipoprotein particle
    • membrane

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References

1. Spoelgen R et al. (2009) Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11. Neuroscience, 158:1460-8. (PubMed:19047013)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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