Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Map6. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a microtubule-associated protein. The encoded protein is a calmodulin-binding and calmodulin-regulated protein that is involved in microtubule stabilization. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Map6
  • performs the following molecular functions:
    • microtubule binding ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Map6:
  • is located in the following cellular components:
    • microtubule
    • perinuclear region of cytoplasm

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Summary text based on GO annotations supported by structural data

• Map6 encodes a protein or proteins that contain the following InterPro domains: Stable tubule-only polypeptide (STOP), STOP/FAM154, indicating that the gene product:
  • participates in the following biological processes:
    • negative regulation of microtubule depolymerization
  • performs the following molecular functions:
    • calmodulin binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Map6 indicates that it:
  • performs the following molecular functions:
    • calmodulin binding
  • is located in the following cellular components:
    • cytoplasm
    • cytoskeleton
    • Golgi apparatus

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References

1. Gory-Faure S et al. (2006) STOP-like protein 21 is a novel member of the STOP family, revealing a Golgi localization of STOP proteins. J Biol Chem, 281:28387-96. (PubMed:16837464)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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