Automated description from the Alliance of Genome Resources
Exhibits several functions, including DNA binding activity; protein dimerization activity; and transcription factor binding activity. Involved in several processes, including animal organ development; chordate embryonic development; and transmembrane receptor protein serine/threonine kinase signaling pathway. Localizes to the cytoplasm; nucleus; and plasma membrane. Used to study osteoarthritis. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 3; Lynch syndrome; and pancreatic cancer. Orthologous to human SMAD3 (SMAD family member 3).