Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cer1. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cer1
  • participates in the following biological processes:
    • anterior/posterior axis specification ^[7]
    • anterior/posterior pattern specification ^[3]
    • negative regulation of activin receptor signaling pathway ^[2]
    • negative regulation of BMP signaling pathway ^{[1, 3]}
    • negative regulation of mesoderm development ^[2]
    • sequestering of BMP in extracellular matrix ^[2]
    • signal transduction involved in regulation of gene expression ^[5]
  • performs the following molecular functions:
    • protein homodimerization activity ^[2]
  • is located in the following cellular components:
    • extracellular region ^[1]
    • extracellular space ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Cer1
  • participates in the following biological processes:
    • ureteric bud development ^[4]
• Researchers have inferred, based on genetic interactions, that the gene product of Cer1
  • participates in the following biological processes:
    • anterior/posterior axis specification based on interactions with Lefty1, Tdgf1 ^{[6, 7]}
    • cell migration involved in gastrulation based on interactions with Lefty1 ^[7]
    • gastrulation based on interactions with Tdgf1 ^[6]
    • negative regulation of cell proliferation based on interactions with Lefty1 ^[7]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cer1:
  • participates in the following biological processes:
    • bone mineralization
    • cellular response to BMP stimulus
    • determination of dorsal identity
    • negative regulation of activin receptor signaling pathway
    • negative regulation of mesoderm development
    • nervous system development
    • sequestering of BMP in extracellular matrix
  • performs the following molecular functions:
    • BMP binding
    • morphogen activity
  • is located in the following cellular components:
    • extracellular region

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cer1 indicates that it:
  • performs the following molecular functions:
    • cytokine activity

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References

1. Belo JA et al. (1997) Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula Mech Dev, 68:45-57. (PubMed:9431803)
2. Belo JA et al. (2000) Cerberus-like is a secreted BMP and nodal antagonist not essential for mouse development [letter] Genesis, 26:265-70. (PubMed:10748465)
3. Biben C et al. (1998) Murine cerberus homologue mCer-1: a candidate anterior patterning molecule. Dev Biol, 194:135-51. (PubMed:9501024)
4. Chi L et al. (2011) A secreted BMP antagonist, Cer1, fine tunes the spatial organization of the ureteric bud tree during mouse kidney development. PLoS One, 6:e27676. (PubMed:22114682)
5. Lee D et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell, 2:497-507. (PubMed:18462699)
6. Liguori GL et al. (2008) Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo. Dev Biol, 315:280-9. (PubMed:18241853)
7. Yamamoto M et al. (2004) Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo. Nature, 428:387-92. (PubMed:15004567)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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