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Gene Ontology Classifications
Pbx/knotted 1 homeobox

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pknox1. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of June 10, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by structural data
  1. Bailey JS et al. (2004) Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1. Mol Endocrinol, 18:1158-70. (PubMed:14764653)
  2. Di Rosa P et al. (2007) The homeodomain transcription factor Prep1 (pKnox1) is required for hematopoietic stem and progenitor cell activity. Dev Biol, 311:324-34. (PubMed:17904118)
  3. Faure AJ et al. (2012) Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules. Genome Res, 22:2163-75. (PubMed:22780989)
  4. Ferretti E et al. (2006) Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype. Mol Cell Biol, 26:5650-62. (PubMed:16847320)
  5. Ferretti E et al. (1999) The PBX-regulating protein PREP1 is present in different PBX-complexed forms in mouse. Mech Dev, 83:53-64. (PubMed:10381567)
  6. Jacobs Y et al. (1999) Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity. Mol Cell Biol, 19:5134-42. (PubMed:10373562)
  7. Knoepfler PS et al. (1997) Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. Proc Natl Acad Sci U S A, 94:14553-8. (PubMed:9405651)
  8. Penkov D et al. (2005) Involvement of Prep1 in the alphabeta T-cell receptor T-lymphocytic potential of hematopoietic precursors. Mol Cell Biol, 25:10768-81. (PubMed:16314502)
  9. Villaescusa JC et al. (2004) Expression of Hox cofactor genes during mouse ovarian follicular development and oocyte maturation. Gene, 330:1-7. (PubMed:15087118)
  10. Yoshioka H et al. (2007) In vivo analysis of developmentally and evolutionarily dynamic protein-DNA interactions regulating transcription of the Pgk2 gene during mammalian spermatogenesis. Mol Cell Biol, 27:7871-85. (PubMed:17875925)
  11. Zhang X et al. (2006) Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development. Dev Biol, 300:748-57. (PubMed:17049510)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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